Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions
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چکیده
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Signal transduction and biological functions of bone morphogenetic proteins.
Bone morphogenetic proteins (BMPs) are multi-functional growth factors and belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1 and 5 are the immediate downstream molecules of BMP receptor and p...
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Epithelial to mesenchymal transition (EMT) is a process in which fully differentiated epithelial cells lose many of their epithelial characteristics and adopt features typical of mesenchymal cells, thus allowing cells to become migratory and invasive. EMT is a critical process in development and its role in cancer and fibrosis is becoming increasingly recognised. It is also becoming apparent th...
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Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and o...
متن کاملOverview of bone morphogenetic proteins.
STUDY DESIGN A literature review was conducted. OBJECTIVES To review the discovery of the bone morphogenetic proteins and describe the bone morphogenetic protein products that will or may be available for clinical use. SUMMARY OF BACKGROUND DATA Bone morphogenetic proteins comprise the osteoinductive component of several tissue engineering products in late-stage development as replacements ...
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ژورنال
عنوان ژورنال: Reproductive Medicine and Biology
سال: 2011
ISSN: 1445-5781
DOI: 10.1007/s12522-011-0082-9